Female EcologiX: Your New Clinical Tool

Learn about your new clinical tool: Female EcologiX Vaginal Health & Microbiome Profile


Female EcologiX™ | Host-Microbiome Analysis

The vaginal microbiome is a key ecosystem, which is host to over 200 species of microorganisms. Unlike other microbiota sites, the vagina is extremely dynamic and is affected by numerous host factors including age, ethnic background, sexual intercourse, changes in hormone levels during pregnancy, menstruation and menopause, genital infections and personal hygiene.

Due to its extensive interaction and cross-talk with host immune responses, small fluctuations in the vaginal microbiota can impact vaginal health significantly. The disruption of homeostasis, termed dysbiosis, has been linked to a multitude of conditions, including bacterial vaginosis (BV), miscarriages, preterm delivery, pelvic inflammatory disease (PID) and increased risk of sexually transmitted infections (STIs).

Analysis and monitoring of the vaginal microbiota is therefore extremely important for health and can be used to inform treatment plans and lifestyle factors.

vaginal ecosystem
Figure 1: Dysbiosis in the vaginal microbiota. Disruption of vaginal Lactobacillus species may result in colonisation and overgrowth of strictly anaerobic bacteria including Prevotella bivia and Gardnerella. Overgrowth of strict anaerobes results in increased levels of pro-inflammatory cytokines, reduced production of lactic acid, reduced production of antimicrobial peptides and thus, pathogen colonisation and epithelial injury. Adapted from Aldunate et al (2015).
The Female EcologiX™ Profile

Methodology:
The profile uses two technologies: quantitative real-time PCR is (q-RT-PCR) is used to quantify the abundance of microbial genes. Enzyme-linked immunosorbent assays (ELISA) are used for the quantification of host proteins

For microbiota composition analysis, the technology detects:

  • Abundance of four key Lactobacillus species (markers for vaginal health)
  • Abundance of strictly anaerobic bacteria (associated with dysbiosis)
  • Abundance of enteric bacteria including Escherichia coli and Staphylococcus aureus(associated with aerobic vaginitis)
  • Abundance of BV-associated bacteria including Gardnerella, Prevotella and Megasphaeraspecies
For host biomarker analysis, the technology detects:
  • pH
  • IL-1β (pro-inflammatory cytokine)

STI panel add-on:

  • Presence of STI pathogen Chlamydia trachomatis
  • Presence of STI viral pathogens herpes simplex virus type 1 (HSV-1; oral herpes) and HSV-2 (genital herpes)

Dependent on microbiota composition and host biomarkers, the profile will report three different states:

  • Healthy vaginal microbiota (homeostasis)
  • Vaginal dysbiosis (microbiota profile and/or host marker profile)
  • STI pathogen detected (STI panel add-on)

Price (RRP)
Female EcologiX™ RRP: £195
Female EcologiX™ + STI panel RRP: £255

Turnaround time
10 working days

 


Materials & Support

Female EcologiX

Downloads:
Sample report
Interpretive guide
Clinical matrix
Clinical considerations (logged-in only)

Consultations:
We offer complimentary consults with our clinical education team. You can book these from your account dashboard.

Coming soon:
Clinical questionnaire
Case study webinars

 


Relevant Education

We are proud to be working with Moira Bradfield, ND – a specialist on female microbiome health, and owner of Intimate Ecology – on two upcoming educational events:

Female Ecology: The Menopausal Vagina

Strategies to question, support and address vaginal health in menopause.
1 hour webinar
5th September 10am (will be recorded)
Free
→ find out more

Female Ecology Mastercourse

Master female ecology in clinical practice with our online 6-week course.
Starts 31st October 2019 (classes recorded)
9 CPD hours
£249
→ find out more

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Female EcologiX™ | Host-Microbiome Analysis The vaginal microbiome is a key ecosystem, which is host to over 200 species of microorganisms. Unlike other microbiota sites, the vagina is extremely dynamic and is ...