Translating host-microbiome research into precision medicine.
Phylo Bioscience™ Laboratory
Phylo Bioscience™ was established in 2018 at Unit DX in Bristol. The need to explore host responses to the microbiome in health and disease, shaped the development of the laboratory and the diagnostic profiles they have developed.
These groundbreaking clinical tools use quantitative realtime polymerase chain reaction (qRT-PCR) to analyse the bacterial, viral and fungal communities of the oral and vaginal cavities in conjunction with key host immunological markers, measured using enzyme linked immunosorbent assays (ELISAs).
The Oral and Female EcologiX™ profiles allow for a deeper understanding of host-microbiome interactions in these key ecosystems.
The vaginal tract is host to over 200 species of microorganisms. It is a dynamic and complex ecosystem comprising fluctuating populations that modulate host immune responses and maintain homeostasis.
Disruption of microbiota composition and functions, termed dysbiosis, has been linked to a multitude of disorders, including: bacterial vaginosis (BV), premature delivery in pregnant women, infertility, miscarriages and increased risk of sexually transmitted infections (STIs).
Analysis and monitoring of the vaginal microbiota is therefore extremely important for health and can be used to inform treatment plans and lifestyle factors.
The Female EcologiX™ vaginal health and microbiome profile uses qRT-PCR and ELISA technologies to provide an accurate, reliable and quantifiable measurement of microbiota abundance and the host immune response.
The impact of non-gastrointestinal microbiomes are often neglected, but in our partnership with Phylo, we are able to champion other key microbial ecosystems. We are proud to offer these clinical tools, which help to align clinical practice with the latest research in this field.
Humphrey Bacchus, MD Invivo
The oral cavity is a complex ecosystem, comprising several habitats including the teeth, gums, tongue and tonsils, all colonised by bacteria. The oral microbiota consists of approximately 600 taxa at the species level, with different groups and subsets inhabiting different niches.
The microbiota of the oral cavity exists as a complex biofilm that remains stable, despite environmental changes. However, dysbiosis, in form of infection, injury, dietary changes and risk-associated factors (e.g. smoking) may disrupt the biofilm community, favouring colonisation and invasion of pathogens.
Disruption of the biofilm community to a pathogenic profile, induces host immune responses, chronic inflammation and ultimately, the development of local and systemic disease. However, much of this damage is reversible if pathogenic communities are reduced, and homeostasis is restored.
The Oral EcologiX™ oral health and microbiome profile uses qRT-PCR and ELISA technologies to provide an accurate, reliable and quantifiable measurement of microbiota abundance and the host immune response.
We will be developing more practitioner-only clinical resources for the EcologiX™ profiles. These will be available in your logged-in practitioner resources and will include patient questionnaires, clinical considerations, case study reviews and webinars.
Debbie Cotton, ND and Sue Camp, MSc are running two webinars introducing the two EcologiX™ profiles on the 1st and 6th August. Click below for more information.
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