The Oral Microbiome | Strain Specific Research

In Vitro Inhibition of Pathogens

Bacterial strains exhibit differing capacities for pathogen inhibition. This in vitro experiment shows the inhibitory ability of several strains against pathogens associated with the development of gingivitis.

In Vitro Inhibition of Biofilm Formation

An important virulent factor in oral health is the formation of biofilms, also known as (dental) plaque. In an in vitro experiment with antibiotic vancomycin resistant Enterococcus faecium, several strains were able to significantly modulate biofilm formation. Nevertheless, supernatants of all probiotic strains had a diminishing effect on biofilm formation and showed a reduction between 37% - 62%.

In Vitro Strengthening of the Immune System

Bacterial strains can also inhibit the development of gingivitis by modulating the immune system. An in vitro screening was performed on bacterial strains for their capacity to induce IL-10, an anti-inflammatory cytokine. Several strains showed a stimulating effect on IL-10 production, and these effects were strain-specific.