Advanced Intestinal Barrier Assessment



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This advanced assessment of the intestinal barrier enables an understanding of the integrity of the barrier, and helps to understand why.

The biomarkers include zonulin, which regulates tight junctions. Diamine oxidase (DAO), which is produced in the microvilli; a deficiency may indicate microvilli atrophy. Certain drugs, foods and bacteria may also suppress its production. DAO breaks down histamine, which is a compound that affects the immune response, physiological function of the digestive tract, and acts as a neurotransmitter. LPS is a bacterial endotoxin. Increased levels are indicative of intestinal permeability via transcellular and paracellular pathways. When LPS is absorbed into systemic circulation it can elicit a strong immune response.

Testing histamine along with diamine oxidase (DAO) levels provides important information that standard food sensitivity tests may not reveal, and may be the real culprit when food sensitivities are suspected.


Sample type: Blood
Turnaround time: 15 days
Lab: Dunwoody Labs


  • Zonulin
  • Diamine oxidase (DAO)
  • Histamine
  • LPS antibodies (IgA, IgG, IgM)

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