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The Oral Microbiome | Strain Specific Research

Probiotic strains have very specific functions and should be chosen accordingly. Additionally, some strains should not be put together in capsules or powder due to their incompatibility. It is a complex science, and it is important to trust the source and their knowledge. Our partners, Winclove, are a family-owned company established in Amsterdam. They specialise in the research, development and manufacturing of probiotic formulations. Below, we highlight their research into oral probiotic strains.


In Vitro Inhibition of Pathogens

Bacterial strains exhibit differing capacities for pathogen inhibition. This in vitro experiment shows the inhibitory ability of several strains against pathogens associated with the development of gingivitis.

in vitro pathogen inhibition

In Vitro Inhibition of Biofilm Formation

An important virulent factor in oral health is the formation of biofilms, also known as (dental) plaque. In an in vitro experiment with antibiotic vancomycin resistant Enterococcus faecium, several strains were able to significantly modulate biofilm formation. Nevertheless, supernatants of all probiotic strains had a diminishing effect on biofilm formation and showed a reduction between 37% – 62%.

in vitro biofilm inhibition

In Vitro Strengthening of the Immune System

Bacterial strains can also inhibit the development of gingivitis by modulating the immune system. An in vitro screening was performed on bacterial strains for their capacity to induce IL-10, an anti-inflammatory cytokine. Several strains showed a stimulating effect on IL-10 production, and these effects were strain-specific.

Oral Bacteria Modulation

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