Education > Article > HMOs as Prebiotics to Reinforce Innate Immune System

HMOs as Prebiotics to Reinforce Innate Immune System

Galactooligosaccharides (GOS) is one of our key supplements to promote a healthy microbiome for immune health and host-microbiome homeostasis.

The gut plays a central role in our innate immute system. A dysbiotic microbiota engendered by stress, ageing, antibiotics etc., impacts negatively on intestinal permeability and promotes endotoxemia. This chronic, low-grade inflammation mobilises the immune response and may negatively impact our ability to evade pathogens.

Galactooligosaccharides (GOS) is one of our key supplements to promote a healthy microbiome for immune health and host-microbiome homeostasis.

Prebiotic Intake for Optimal Immune Function
Human milk oligosaccharides (HMOs) are complex sugars representing the third-largest solid component in human milk after fat and lactose. Among them, galactooligosaccharides (GOS) are demonstrated to be an efficient prebiotic solution:

  • Non-digestible, short-chain soluble fibres,
  • Low-doses
  • Resistant to gastric acids and hydrolysis by human enzymes
  • Resistant over time
  • Selectively utilised by Bifidobacteria & Lactobacilli, which have established health benefits


Bio.Me™ Prebio GOS offers galactooligosaccharides with 9% 4’-galactosyllactose, a unique HMO with a proven beneficial effect on the regulation of gut microflora at a low dose.

GOS For The Enhancement of Innate Immune Function
The prebiotic functions of GOS at 70% concentration have a beneficial effect on the key stages of innate immunity by their action on barrier function and chronic low-grade inflammation. This helps balance the immune system, optimising its response when needed.

STEP 1: GOS direct effects on gut barrier function
GOS are effective in the transfer epithelium. GOS may improve physical intestinal barrier function, via its direct effects on:

  • The inhibition of pathogenic bacteria adhesion
  • Tight junction reinforcement

STEP 2: Modulation of gram positive bacteria population
GOS promotes biodiversity by amplifying beneficial Gram-positive lactic acid bacteria and Bifidobacteria growth, which decreases LPS-associated low-grade inflammation.

STEP 3: Healthy microbiota for optimal anti-inflammatory response
GOS modulates innate cell recruitment and promotes a healthy inflammatory response, contributing to the homeostasis of the immune system and enabling optimal immune function at times of need.

Bio.Me™ Prebio GOS

  • 70% concentrated GOS, including 9% of 4’-galactosyllactose
  • Patented ingredient
  • Food-based & GRAS certified, GMO-free, gluten-free, Halal certification
  • Soluble & neutral taste
  • Indicated for bowel symptoms, immune health and skin health

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